SARS-CoV-2 specific immune-signature in direct contacts of COVID-19 cases protect them from contracting disease: A Retrospective Study

  1. Sunil K. Raghav
  2. Kaushik Sen
  3. Arup Ghosh
  4. Sudeshna Datta
  5. Abdul Ahad
  6. Atimukta Jha
  7. Sanchari Chatterjee
  8. Sandhya Suranjika
  9. Soumya Sengupta
  10. Gargee Bhattacharya
  11. Omprakash Shriwas
  12. Kiran Avula
  13. Jayasingh Kshatri
  14. Punit Prasad
  15. Ajay K. Parida
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Abstract

The response to SARS-CoV-2 is largely impacted by the level of exposure and the status of immunity. The nature of protection shown by direct contacts of COVID-19 positive patients is quite intriguing to note. We aimed to study the immune differences reinforcing contact individuals in circumventing the disease. Our observation showed direct contacts of PCR positive patients developed elevated neutralizing antibody titres and cytokine levels. On the other hand, single cell data revealed differential usage of V(D)J genes and unique BCR clonotypes imparting protective immune signatures.

Topics

serologic tests, immunoglobulin a, immunoglobulin g, immunoglobulin m, antibody titre; cytokine levels; virus neutralization; V(D)J sequencing; BCR clonotypes

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