Past SARS-CoV-2 infection elicits a strong immune response after a single vaccine dose

  1. Rossana Elena Chahla
  2. Rodrigo HernĂĄn Tomas-Grau
  3. Silvia Inés Cazorla
  4. Diego Ploper
  5. Esteban Vera Pingitore
  6. MĂłnica Aguilar LĂłpez
  7. Patricia Aznar
  8. Malena Alcorta
  9. Eva MarĂ­a del Mar VĂ©lez
  10. AgustĂ­n Stagnetto
  11. César Luís Ávila
  12. Carolina Maldonado-Galdeano
  13. Sergio BenjamĂ­n Socias
  14. Dar Heinze
  15. Silvia Adriana Navarro
  16. Conrado Llapur
  17. Dardo Costas
  18. Isolina Flores
  19. Gabriela Apfelbaum
  20. RaĂșl Mostoslavsky
  21. Gustavo Mostoslavsky
  22. Gabriela PerdigĂłn
  23. Rosana Nieves ChehĂ­n
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Abstract

We hypothesized that in individuals with previous SARS-CoV-2 infection, the first vaccine dose would work as a booster, eliciting a faster and more intense immune response. We herein describe antibody responses to the first and second doses of Gam-COVID-Vac (SPUTNIK V) vaccine in health personnel of Tucumán, Argentina, with previous COVID-19 and compared it with uninfected personnel. Individuals with anti-SARS-CoV-2 titers at baseline showed significantly higher responses to the first dose than people with no prior history of disease (p <0.0001), with titers higher to those registered after the second dose in the control group, representing a clear secondary antibody response. This suggests that a single dose of SPUTNIK V for people with previous SARS-CoV-2 infection could contribute to a better use of available doses.

One-Sentence Summary

First vaccine dose in subjects with prior COVID19 elicits a higher antibody response than two doses in uninfected individuals

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