The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients

  1. Elisa Teyssou
  2. Cathia Soulie
  3. Benoit Visseaux
  4. Sidonie Lambert-Niclot
  5. Valentine Ferre
  6. Stéphane Marot
  7. Aude Jary
  8. Sophie Sayon
  9. Karen Zafilaza
  10. Valentin Leducq
  11. Aurélie Schnuriger
  12. Basma Abdi
  13. Marc Wirden
  14. Nadhira Houhou-Fidouh
  15. Charlotte Charpentier
  16. Laurence Morand-Joubert
  17. Sonia Burrel
  18. Diane Descamps
  19. Vincent Calvez
  20. Anne Geneviève Marcelin
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Abstract

The 501Y.V2 and the 501Y.V1 SARS-CoV-2 variants emerged and spread rapidly into the world. We analysed the viral load of 643 nasopharyngeal samples of COVID-19 patients at diagnosis and found that the 501Y.V1 and the 501Y.V2 variants presented a viral load three to ten times and two times higher than the historical variants, respectively.

Highlights

  • Viral load in COVID-19 patient nasopharyngeal samples was different between variants.

  • The 501Y.V2 variant had a viral load 2 times higher than the historical variants

  • The 501Y.V2 variant had a viral load slightly lower than the 501Y.V1

  • The 501Y.V1 variant had a viral load 3-10 times higher than the historical variants

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