A unique SARS-CoV-2 spike protein P681H strain detected in Israel

  1. Neta S. Zuckerman
  2. Shay Fleishon
  3. Efrat Bucris
  4. Dana Bar-Ilan
  5. Michal Linial
  6. Itay Bar-Or
  7. Victoria Indenbaum
  8. Merav Weil
  9. Israel National Consortium for SARS-CoV-2 sequencing
  10. Ella Mendelson
  11. Michal Mandelboim
  12. Orna Mor
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Abstract

Routine detection, surveillance and reporting of SARS-CoV-2 novel variants is important, as these threaten to hinder vaccination efforts. Herein we report a local novel strain that includes a non-synonymous mutation in the spike (S) protein - P681H and additional synonymous mutations. The P681H Israeli strain has not been associated with higher infection rates and was neutralized by sera from vaccinated individuals in comparable levels to the B.1.1.7 strain and a non-P681H strain from Israel.

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