Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum

  1. Timothy A. Bates
  2. Hans C. Leier
  3. Zoe L. Lyski
  4. Savannah K. McBride
  5. Felicity J. Coulter
  6. Jules B. Weinstein
  7. James R. Goodman
  8. Zhengchun Lu
  9. Sarah A. R. Siegel
  10. Peter Sullivan
  11. Matt Strnad
  12. Amanda E. Brunton
  13. David X. Lee
  14. Marcel E. Curlin
  15. William B. Messer
  16. Fikadu G. Tafesse
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Abstract

We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more pronounced in the vaccine cohort, both B.1.1.7 and B.1.351 show significantly reduced levels of neutralization by vaccinated and convalescent sera. Age is negatively correlated with neutralization in vaccinee, and levels of variant-specific RBD antibodies are proportional to neutralizing activities.

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