A distinct metabolic profile associated with a fatal outcome in COVID-19 patients during early epidemic in Italy

  1. Elisa Saccon
  2. Alessandra Bandera
  3. Mariarita Sciumè
  4. Flora Mikeloff
  5. Abid Ali Lashari
  6. Stefano Aliberti
  7. Michael Sachs
  8. Filippo Billi
  9. Francesco Blasi
  10. Erin Gabriel
  11. Giorgio Costantino
  12. Pasquale De Roberto
  13. Shuba Krishnan
  14. Andrea Gori
  15. Flora Peyvandi
  16. Luigia Scudeller
  17. Christian L. Lorson
  18. Luca Valenti
  19. Kamal Singh
  20. Luca Baldini
  21. Nicola Stefano Fracchiolla
  22. Ujjwal Neogi
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Abstract

Leveraging the unique biological resource based upon the initial COVID-19 patients in Policlinico di Milano (Italy), our study provides the first metabolic profile associated with a fatal outcome. The identification of potential predictive biomarkers offers a vital opportunity to employ metabolomics in a clinical setting as diagnostic tool of disease prognosis upon hospital admission.

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