INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T cell Activity Against Global SARS-CoV-2 Variants

  1. Viviane M. Andrade
  2. Aaron Christensen-Quick
  3. Joseph Agnes
  4. Jared Tur
  5. Charles Reed
  6. Richa Kalia
  7. Idania Marrero
  8. Dustin Elwood
  9. Katherine Schultheis
  10. Mansi Purwar
  11. Emma Reuschel
  12. Trevor McMullan
  13. Patrick Pezzoli
  14. Kim Kraynyak
  15. Albert Sylvester
  16. Mammen P. Mammen
  17. Pablo Tebas
  18. J. Joseph Kim
  19. David B. Weiner
  20. Trevor R.F. Smith
  21. Stephanie J. Ramos
  22. Laurent M. Humeau
  23. Jean D. Boyer
  24. Kate E. Broderick
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Abstract

Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.

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