Multiplex Fragment Analysis Identifies SARS-CoV-2 Variants

  1. A.E. Clark
  2. Z. Wang
  3. B. Cantarel
  4. M. Kanchwala
  5. C. Xing
  6. L. Chen
  7. P. Irwin
  8. Y. Xu
  9. D. Oliver
  10. F. Lee
  11. J.R. Gagan
  12. L. Filkins
  13. A. Muthukumar
  14. J.Y. Park
  15. R. Sarode
  16. J.A. SoRelle
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Abstract

The rapid spread of SARS-CoV-2 Variants of Concern (VOC) necessitates systematic efforts for epidemiological surveillance. The current method for identifying variants is viral whole genome sequencing (WGS). Broad clinical adoption of sequencing is limited by costly equipment, bioinformatics support, technical expertise, and time for implementation. Here we describe a scalable, multiplex, non-sequencing-based capillary electrophoresis assay to affordably screen for SARS-CoV-2 VOC.

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