Surging COVID-19 in Bangladesh driven by B.1.351 variant

  1. Eric Brum
  2. Senjuti Saha
  3. Ayesha Sania
  4. Arif Mohammad Tanmoy
  5. Yogesh Hooda
  6. Afroza Akter Tanni
  7. Sharmistha Goswami
  8. Syed Muktadir Al Sium
  9. Mohammad Saiful Islam Sajib
  10. Roly Malaker
  11. Shuborno Islam
  12. Nikkon Sarker
  13. Samir K Saha
  14. Shayan Chowdhury
  15. Yacob Haddou
  16. Elaine Ferguson
  17. Mikolaj Kundegorski
  18. Nabila Purno
  19. Motahara Tasneem
  20. Shams El Arifeen
  21. AMS Alamgir
  22. Anir Chowdhury
  23. Katie Hampson
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Abstract

A dramatic resurgence of COVID-19 cases and deaths in Bangladesh in March 2021 coincided with the SARS-CoV-2 B.1.351 (501Y.V2) variant of concern rapidly becoming the dominant circulating variant. Concurrently, increasing numbers of reinfections have been detected and the effective Reproductive number, R t , has doubled, despite high levels of prior infection in Dhaka city. These data support the prediction that acquired immunity from past infection provides reduced protection against B.1.351, and highlights the major public health concern posed by immune escape variants, especially in populations where vaccination coverage remains low.

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