SARS-CoV-2 Seroprevalence and Risk Factors among Convalescents in Sichuan Province, China: a retrospective cohort study

  1. Lijun Zhou
  2. Cheng Li
  3. Huiping Yang
  4. Heng Yuan
  5. Ming Pan
  6. Xiuwei Cheng
  7. Chongkun Xiao
  8. Xiaoyan Su
  9. Yuanfang Zhu
  10. Jianan Xu
  11. Jianxiang Tang
  12. Xunbo Du
  13. Huanwen Peng
  14. Chen Xiao
  15. Tao Huang
  16. Hongxiu Liao
  17. Deqiang Xian
  18. Hongxiu Liao
  19. HaoZhou Wang
  20. Wenwu Liu
  21. Zhou Ping
  22. Zhengdong Zhang
  23. Liu Juan
  24. Xianping Wu
  25. Tao Zhang
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Abstract

Objectives

To understand SARS-CoV-2 seroprevalence of convalescents and assess their the immunity. Furthermore, we intend to explore the association between antibody levels and with demographic factors.

Methods

177 COVID-19 convalescents in Sichuan Province were voluntarily participated in our study. 363 serum samples were collected from June, 2020 to November, 2020. Duration of seroprevelance in these convalescents and their demographic characteristics were described, and the risk factors to antibody levels were analysed.

Results

Men had more than twice the odds of having IgM antibody positive compared with women (OR=2.419, 95% CI:[1.232, 4.751]). Participants without symptoms were nearly 0.5 times IgG seropositive than those with symptoms (OR=0.455, 95% CI: [0.220, 0.940]). People aged≥60 years were nearly 3 times IgG seropositive than those who aged < 20 years (OR=2.986, 95% CI: [1.058, 8.432]). Seroprevalence in asymptomatic declined quicker than symptomatic.

Conclusions

Age and gender may affect the antibody levels and seroprevalence. Asymptomatic appeared more easier to turn to seronegative than symptomatic.

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