Individuals who were mildly symptomatic following infection with SARS-CoV-2 B.1.1.28 have neutralizing antibodies to the P.1 variant

  1. Maria Cassia Mendes-Correa
  2. Lucy S. Villas-Boas
  3. Ana Luiza Bierrenbach
  4. Anderson de Paula
  5. Tania Regina Tozetto-Mendoza
  6. Fabio E. Leal
  7. Wilton Freire
  8. Heuder Gustavo Oliveira Paiao
  9. Andrea B C Ferraz
  10. Steven S. Witkin
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Abstract

Objectives

To evaluate if antibodies induced by infection with a different SARS-CoV-2 virus strain neutralize the P.1 variant.

Methods

Convalescent sera from 60 individuals following a documented SARS-CoV-2 infection were assayed for neutralizing antibody titer against both strains.

Results

Fifty-six and 50 sera were positive for neutralizing antibodies against the ancestral and P.1 strains, respectively. Neutralization titers were higher against the ancestral strain, but in the majority of patients differences did not differ by more than a single dilution.

Conclusions

Neutralizing antibodies that were generated following infection with SARS-CoV-2 B.1.1.28 were effective in vitro , against the SARS-CoV-2 P.1. variant.

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