Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan

  1. Ho Namkoong
  2. Ryuya Edahiro
  3. Koichi Fukunaga
  4. Yuya Shirai
  5. Kyuto Sonehara
  6. Hiromu Tanaka
  7. Ho Lee
  8. Takanori Hasegawa
  9. Masahiro Kanai
  10. Tatsuhiko Naito
  11. Kenichi Yamamoto
  12. Ryunosuke Saiki
  13. Takayoshi Hyugaji
  14. Eigo Shimizu
  15. Kotoe Katayama
  16. Kazuhisa Takahashi
  17. Norihiro Harada
  18. Toshio Naito
  19. Makoto Hiki
  20. Yasushi Matsushita
  21. Haruhi Takagi
  22. Ryousuke Aoki
  23. Ai Nakamura
  24. Sonoko Harada
  25. Hitoshi Sasano
  26. Hiroki Kabata
  27. Katsunori Masaki
  28. Hirofumi Kamata
  29. Shinnosuke Ikemura
  30. Shotaro Chubachi
  31. Satoshi Okamori
  32. Hideki Terai
  33. Atsuho Morita
  34. Takanori Asakura
  35. Junichi Sasaki
  36. Hiroshi Morisaki
  37. Yoshifumi Uwamino
  38. Kosaku Nanki
  39. Yohei Mikami
  40. Sho Uchida
  41. Shunsuke Uno
  42. Rino Ishihara
  43. Yuta Matsubara
  44. Tomoyasu Nishimura
  45. Takanori Ogawa
  46. Takashi Ishiguro
  47. Taisuke Isono
  48. Shun Shibata
  49. Yuma Matsui
  50. Chiaki Hosoda
  51. Kenji Takano
  52. Takashi Nishida
  53. Yoichi Kobayashi
  54. Yotaro Takaku
  55. Noboru Takayanagi
  56. Soichiro Ueda
  57. Ai Tada
  58. Masayoshi Miyawaki
  59. Masaomi Yamamoto
  60. Eriko Yoshida
  61. Reina Hayashi
  62. Tomoki Nagasaka
  63. Sawako Arai
  64. Yutaro Kaneko
  65. Kana Sasaki
  66. Etsuko Tagaya
  67. Masatoshi Kawana
  68. Ken Arimura
  69. Kunihiko Takahashi
  70. Tatsuhiko Anzai
  71. Satoshi Ito
  72. Akifumi Endo
  73. Yuji Uchimura
  74. Yasunari Miyazaki
  75. Takayuki Honda
  76. Tomoya Tateishi
  77. Shuji Tohda
  78. Naoya Ichimura
  79. Kazunari Sonobe
  80. Chihiro Sassa
  81. Jun Nakajima
  82. Yasushi Nakano
  83. Yukiko Nakajima
  84. Ryusuke Anan
  85. Ryosuke Arai
  86. Yuko Kurihara
  87. Yuko Harada
  88. Kazumi Nishio
  89. Tetsuya Ueda
  90. Masanori Azuma
  91. Ryuichi Saito
  92. Toshikatsu Sado
  93. Yoshimune Miyazaki
  94. Ryuichi Sato
  95. Yuki Haruta
  96. Tadao Nagasaki
  97. Yoshinori Yasui
  98. Yoshinori Hasegawa
  99. Yoshikazu Mutoh
  100. Tomonori Sato
  101. Reoto Takei
  102. Satoshi Hagimoto
  103. Yoichiro Noguchi
  104. Yasuhiko Yamano
  105. Hajime Sasano
  106. Sho Ota
  107. Yasushi Nakamori
  108. Kazuhisa Yoshiya
  109. Fukuki Saito
  110. Tomoyuki Yoshihara
  111. Daiki Wada
  112. Hiromu Iwamura
  113. Syuji Kanayama
  114. Shuhei Maruyama
  115. Takashi Yoshiyama
  116. Ken Ohta
  117. Hiroyuki Kokuto
  118. Hideo Ogata
  119. Yoshiaki Tanaka
  120. Kenichi Arakawa
  121. Masafumi Shimoda
  122. Takeshi Osawa
  123. Hiroki Tateno
  124. Isano Hase
  125. Shuichi Yoshida
  126. Shoji Suzuki
  127. Miki Kawada
  128. Hirohisa Horinouchi
  129. Fumitake Saito
  130. Keiko Mitamura
  131. Masao Hagihara
  132. Junichi Ochi
  133. Tomoyuki Uchida
  134. Rie Baba
  135. Daisuke Arai
  136. Takayuki Ogura
  137. Hidenori Takahashi
  138. Shigehiro Hagiwara
  139. Genta Nagao
  140. Shunichiro Konishi
  141. Ichiro Nakachi
  142. Koji Murakami
  143. Mitsuhiro Yamada
  144. Hisatoshi Sugiura
  145. Hirohito Sano
  146. Shuichiro Matsumoto
  147. Nozomu Kimura
  148. Yoshinao Ono
  149. Hiroaki Baba
  150. Yusuke Suzuki
  151. Sohei Nakayama
  152. Keita Masuzawa
  153. Shinichi Namba
  154. Ken Suzuki
  155. Nobuyuki Hizawa
  156. Takayuki Shiroyama
  157. Satoru Miyawaki
  158. Yusuke Kawamura
  159. Akiyoshi Nakayama
  160. Hirotaka Matsuo
  161. Yuichi Maeda
  162. Takuro Nii
  163. Yoshimi Noda
  164. Takayuki Niitsu
  165. Yuichi Adachi
  166. Takatoshi Enomoto
  167. Saori Amiya
  168. Reina Hara
  169. Toshihiro Kishikawa
  170. Shuhei Yamada
  171. Shuhei Kawabata
  172. Noriyuki Kijima
  173. Masatoshi Takagaki
  174. Noa Sasa
  175. Yuya Ueno
  176. Motoyuki Suzuki
  177. Norihiko Takemoto
  178. Hirotaka Eguchi
  179. Takahito Fukusumi
  180. Takao Imai
  181. Munehisa Fukushima
  182. Haruhiko Kishima
  183. Hidenori Inohara
  184. Kazunori Tomono
  185. Kazuto Kato
  186. Meiko Takahashi
  187. Fumihiko Matsuda
  188. Haruhiko Hirata
  189. Yoshito Takeda
  190. Hidefumi Koh
  191. Tadashi Manabe
  192. Yohei Funatsu
  193. Fumimaro Ito
  194. Takahiro Fukui
  195. Keisuke Shinozuka
  196. Sumiko Kohashi
  197. Masatoshi Miyazaki
  198. Tomohisa Shoko
  199. Mitsuaki Kojima
  200. Tomohiro Adachi
  201. Motonao Ishikawa
  202. Kenichiro Takahashi
  203. Takashi Inoue
  204. Toshiyuki Hirano
  205. Keigo Kobayashi
  206. Hatsuyo Takaoka
  207. Kazuyoshi Watanabe
  208. Naoki Miyazawa
  209. Yasuhiro Kimura
  210. Reiko Sado
  211. Hideyasu Sugimoto
  212. Akane Kamiya
  213. Naota Kuwahara
  214. Akiko Fujiwara
  215. Tomohiro Matsunaga
  216. Yoko Sato
  217. Takenori Okada
  218. Yoshihiro Hirai
  219. Hidetoshi Kawashima
  220. Atsuya Narita
  221. Kazuki Niwa
  222. Yoshiyuki Sekikawa
  223. Koichi Nishi
  224. Masaru Nishitsuji
  225. Mayuko Tani
  226. Junya Suzuki
  227. Hiroki Nakatsumi
  228. Takashi Ogura
  229. Hideya Kitamura
  230. Eri Hagiwara
  231. Kota Murohashi
  232. Hiroko Okabayashi
  233. Takao Mochimaru
  234. Shigenari Nukaga
  235. Ryosuke Satomi
  236. Yoshitaka Oyamada
  237. Nobuaki Mori
  238. Tomoya Baba
  239. Yasutaka Fukui
  240. Mitsuru Odate
  241. Shuko Mashimo
  242. Yasushi Makino
  243. Kazuma Yagi
  244. Mizuha Hashiguchi
  245. Junko Kagyo
  246. Tetsuya Shiomi
  247. Satoshi Fuke
  248. Hiroshi Saito
  249. Tomoya Tsuchida
  250. Shigeki Fujitani
  251. Mumon Takita
  252. Daiki Morikawa
  253. Toru Yoshida
  254. Takehiro Izumo
  255. Minoru Inomata
  256. Naoyuki Kuse
  257. Nobuyasu Awano
  258. Mari Tone
  259. Akihiro Ito
  260. Yoshihiko Nakamura
  261. Kota Hoshino
  262. Junichi Maruyama
  263. Hiroyasu Ishikura
  264. Tohru Takata
  265. Toshio Odani
  266. Masaru Amishima
  267. Takeshi Hattori
  268. Yasuo Shichinohe
  269. Takashi Kagaya
  270. Toshiyuki Kita
  271. Kazuhide Ohta
  272. Satoru Sakagami
  273. Kiyoshi Koshida
  274. Kentaro Hayashi
  275. Tetsuo Shimizu
  276. Yutaka Kozu
  277. Hisato Hiranuma
  278. Yasuhiro Gon
  279. Namiki Izumi
  280. Kaoru Nagata
  281. Ken Ueda
  282. Reiko Taki
  283. Satoko Hanada
  284. Kodai Kawamura
  285. Kazuya Ichikado
  286. Kenta Nishiyama
  287. Hiroyuki Muranaka
  288. Kazunori Nakamura
  289. Naozumi Hashimoto
  290. Keiko Wakahara
  291. Sakamoto Koji
  292. Norihito Omote
  293. Akira Ando
  294. Nobuhiro Kodama
  295. Yasunari Kaneyama
  296. Shunsuke Maeda
  297. Takashige Kuraki
  298. Takemasa Matsumoto
  299. Koutaro Yokote
  300. Taka-Aki Nakada
  301. Ryuzo Abe
  302. Taku Oshima
  303. Tadanaga Shimada
  304. Masahiro Harada
  305. Takeshi Takahashi
  306. Hiroshi Ono
  307. Toshihiro Sakurai
  308. Takayuki Shibusawa
  309. Yoshifumi Kimizuka
  310. Akihiko Kawana
  311. Tomoya Sano
  312. Chie Watanabe
  313. Ryohei Suematsu
  314. Hisako Sageshima
  315. Ayumi Yoshifuji
  316. Kazuto Ito
  317. Saeko Takahashi
  318. Kota Ishioka
  319. Morio Nakamura
  320. Makoto Masuda
  321. Aya Wakabayashi
  322. Hiroki Watanabe
  323. Suguru Ueda
  324. Masanori Nishikawa
  325. Yusuke Chihara
  326. Mayumi Takeuchi
  327. Keisuke Onoi
  328. Jun Shinozuka
  329. Atsushi Sueyoshi
  330. Yoji Nagasaki
  331. Masaki Okamoto
  332. Sayoko Ishihara
  333. Masatoshi Shimo
  334. Yoshihisa Tokunaga
  335. Yu Kusaka
  336. Takehiko Ohba
  337. Susumu Isogai
  338. Aki Ogawa
  339. Takuya Inoue
  340. Satoru Fukuyama
  341. Yoshihiro Eriguchi
  342. Akiko Yonekawa
  343. Keiko Kan-o
  344. Koichiro Matsumoto
  345. Kensuke Kanaoka
  346. Shoichi Ihara
  347. Kiyoshi Komuta
  348. Yoshiaki Inoue
  349. Shigeru Chiba
  350. Kunihiro Yamagata
  351. Yuji Hiramatsu
  352. Hirayasu Kai
  353. Koichiro Asano
  354. Tsuyoshi Oguma
  355. Yoko Ito
  356. Satoru Hashimoto
  357. Masaki Yamasaki
  358. Yu Kasamatsu
  359. Yuko Komase
  360. Naoya Hida
  361. Takahiro Tsuburai
  362. Baku Oyama
  363. Minoru Takada
  364. Hidenori Kanda
  365. Yuichiro Kitagawa
  366. Tetsuya Fukuta
  367. Takahito Miyake
  368. Shozo Yoshida
  369. Shinji Ogura
  370. Shinji Abe
  371. Yuta Kono
  372. Yuki Togashi
  373. Hiroyuki Takoi
  374. Ryota Kikuchi
  375. Shinichi Ogawa
  376. Tomouki Ogata
  377. Shoichiro Ishihara
  378. Arihiko Kanehiro
  379. Shinji Ozaki
  380. Yasuko Fuchimo
  381. Sae Wada
  382. Nobukazu Fujimoto
  383. Kei Nishiyama
  384. Mariko Terashima
  385. Satoru Beppu
  386. Kosuke Yoshida
  387. Osamu Narumoto
  388. Hideaki Nagai
  389. Nobuharu Ooshima
  390. Mitsuru Motegi
  391. Akira Umeda
  392. Kazuya Miyagawa
  393. Hisato Shimada
  394. Mayu Endo
  395. Yoshiyuki Ohira
  396. Masafumi Watanabe
  397. Sumito Inoue
  398. Akira Igarashi
  399. Masamichi Sato
  400. Hironori Sagara
  401. Akihiko Tanaka
  402. Shin Ohta
  403. Tomoyuki Kimura
  404. Yoko Shibata
  405. Yoshinori Tanino
  406. Takefumi Nikaido
  407. Hiroyuki Minemura
  408. Yuki Sato
  409. Yuichiro Yamada
  410. Takuya Hashino
  411. Masato Shinoki
  412. Hajime Iwagoe
  413. Hiroshi Takahashi
  414. Kazuhiko Fujii
  415. Hiroto Kishi
  416. Masayuki Kanai
  417. Tomonori Imamura
  418. Tatsuya Yamashita
  419. Masakiyo Yatomi
  420. Toshitaka Maeno
  421. Shinichi Hayashi
  422. Mai Takahashi
  423. Mizuki Kuramochi
  424. Isamu Kamimaki
  425. Yoshiteru Tominaga
  426. Tomoo Ishii
  427. Mitsuyoshi Utsugi
  428. Akihiro Ono
  429. Toru Tanaka
  430. Takeru Kashiwada
  431. Kazue Fujita
  432. Yoshinobu Saito
  433. Masahiro Seike
  434. Yosuke Omae
  435. Yasuhito Nannya
  436. Takafumi Ueno
  437. Tomomi Takano
  438. Kazuhiko Katayama
  439. Masumi Ai
  440. Atsushi Kumanogoh
  441. Toshiro Sato
  442. Naoki Hasegawa
  443. Katsushi Tokunaga
  444. Makoto Ishii
  445. Ryuji Koike
  446. Yuko Kitagawa
  447. Akinori Kimura
  448. Seiya Imoto
  449. Satoru Miyano
  450. Seishi Ogawa
  451. Takanori Kanai
  452. Yukinori Okada
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Abstract

To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirus disease 2019 (COVID-19), is an emerging issue in the face of the current devastating pandemic. Here, we report a genome-wide association study (GWAS) of COVID-19 in a Japanese population led by the Japan COVID-19 Task Force, as one of the initial discovery GWAS studies performed on a non-European population. Enrolling a total of 2,393 cases and 3,289 controls, we not only replicated previously reported COVID-19 risk variants (e.g., LZTFL1, FOXP4, ABO, and IFNAR2), but also found a variant on 5q35 (rs60200309-A at DOCK2) that was associated with severe COVID-19 in younger (<65 years of age) patients with a genome-wide significant p-value of 1.2 × 10-8 (odds ratio = 2.01, 95% confidence interval = 1.58-2.55). This risk allele was prevalent in East Asians, including Japanese (minor allele frequency [MAF] = 0.097), but rarely found in Europeans. Cross-population Mendelian randomization analysis made a causal inference of a number of complex human traits on COVID-19. In particular, obesity had a significant impact on severe COVID-19. The presence of the population-specific risk allele underscores the need of non-European studies of COVID-19 host genetics.

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