Assessment of the infectious threshold of SARS-CoV-2 in primary airway epithelial cells

  1. Manel Essaidi-Laziosi
  2. Francisco Javier Perez Rodriguez
  3. Pascale Sattonnet-Roche
  4. Nicolas Hulo
  5. Frederique Jacquerioz
  6. Laurent Kaiser
  7. Isabella Eckerle
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Abstract

Comparison of virus isolation success from clinical samples across a range of viral loads inoculated in parallel on Vero E6 and human airway epithelia (HAE) showed lower success of virus isolation in HAE, suggesting an overestimation of actual infectiousness in humans using Vero E6 cell lines, commonly considered as reference.

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