Dynamic of humoral response to SARS-CoV-2 anti Nucleocapsid and Spike proteins after CoronaVac vaccination

  1. Lucas Bochnia-Bueno
  2. Sergio Monteiro De Almeida
  3. Sonia Mara Raboni
  4. Douglas Adamoski
  5. Ludmilla Louise Moreira Amadeu
  6. Suzana Carstensen
  7. Meri Bordignon Nogueira
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Abstract

Background

This study aimed to calculate the seroconversion rate of the CoronaVac vaccine in healthcare workers (HCWs) after immunization.

Methods

Serum samples from 133 HCWs from Southern Brazil were collected one day before (Day 0) and +10, +20, +40, + 60, +110 days after administering the vaccine’s first dose. Immunoglobulin G (IgG) was quantified using immunoassays for anti-N-protein (nucleocapsid) antibodies (Abbott, Sligo, Ireland) and for anti-S1 (spike) protein antibodies (Euroimmun, Lübeck, Germany).

Results

Seroconversion by day 40 occurred in 129 (97%) HCWs for the S1 protein, and in 69 (51.87%) HCWs for the N protein. An absence of IgG antibodies (by both methodologies), occurred in two (1.5%) HCWs undergoing semiannual rituximab administration, and also in another two (1.5%) HCWs with no apparent reason.

Conclusion

This study showed that CoronaVac has a high seroconversion rate when evaluated in an HCW population.

Funding

This work was supported by the PROPLAN/Federal University of Paraná, Curitiba-Paraná, Brazil; FINEP, Funder of Studies and Projects, Ministry of Science, Technology and Innovation, Brazil Institutional Network, Project: Laboratories for Diagnostic Tests for COVID-19 (0494/20).

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