Variants of concern are overrepresented among post-vaccination breakthrough infections of SARS-CoV-2 in Washington State

  1. Abbye E. McEwen
  2. Seth Cohen
  3. Chloe Bryson-Cahn
  4. Catherine Liu
  5. Steven A. Pergam
  6. John Lynch
  7. Adrienne Schippers
  8. Kathy Strand
  9. Estella Whimbey
  10. Nandita S Mani
  11. Allison J. Zelikoff
  12. Vanessa A. Makarewicz
  13. Elizabeth R. Brown
  14. Shah A. Mohamed Bakhash
  15. Noah R. Baker
  16. Jared Castor
  17. Robert J. Livingston
  18. Meei-Li Huang
  19. Keith R. Jerome
  20. Alexander L. Greninger
  21. Pavitra Roychoudhury
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Abstract

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOC) and had a median Ct of 20.2 (IQR=17.1-23.3). When compared to 5174 contemporaneous samples sequenced in our laboratory, VOC were significantly enriched among breakthrough infections (p < .05).

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