SARS-CoV-2 shedding, infectivity and evolution in an immunocompromised adult patient

  1. Maria Cassia Mendes-Correa
  2. Fábio Ghilardi
  3. Matias Chiarastelli Salomão
  4. Lucy S. Villas-Boas
  5. Anderson Vicente de Paula
  6. Tania Regina Tozetto-Mendoza
  7. Wilton Freire
  8. Flavia C. Sales
  9. Camila M. Romano
  10. Ingra M. Claro
  11. Leandro Menezes de Souza
  12. Jessica F. Ramos
  13. Heuder Gustavo Oliveira Paiao
  14. Roberta Shcoinik Szor
  15. Esper Georges Kallas
  16. Ester C. Sabino
  17. Steven S. Witkin
  18. Nuno R. Faria
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Abstract

This report describes a persistent SARS-CoV-2 infection of at least 218 days in a male, in his 40’s who had undergone a prior autologous hematopoietic stem cell transplant due to a diffuse large B-cell lymphoma. He did not manifest a humoral immune response to the virus. Whole-genome sequencing and viral cultures confirmed a continual infection with a replication-positive virus that had undergone genetic variation for at least 196 days following symptom onset.

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