Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2

  1. Takahiro Kageyama
  2. Shigeru Tanaka
  3. Keishi Etori
  4. Koto Hattori
  5. Kazusa Miyachi
  6. Tadamichi Kasuya
  7. Taro Iwamoto
  8. Kei Ikeda
  9. Hidetoshi Igari
  10. Koutaro Yokote
  11. Hiroshi Nakajima
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Abstract

We analyzed peripheral blood mononuclear cells (PBMCs) of each 20 individuals with a high anti-SARS-CoV-2 antibody titer and a low antibody titer out of 1,774 healthcare workers who received BNT162b2 mRNA vaccine. A higher antibody titer was associated with the frequencies of naïve and transitional B cells before vaccination. In addition, fold changes in the frequency of activated CD8 + T cells upon vaccination were correlated with the antibody titers.

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