Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection

  1. Whitney E. Harrington
  2. Yonghou Jiang
  3. Fergal Duffy
  4. Jennifer Hadlock
  5. Andrew Raappana
  6. Sheila Styrchak
  7. Ingrid Beck
  8. William Chour
  9. John Houck
  10. Venkata Duvvuri
  11. Winnie Yeung
  12. Micaela Haglund
  13. Jackson Wallner
  14. Julie A. Wallick
  15. Samantha Hardy
  16. Alyssa Oldroyd
  17. Daisy Ko
  18. Ana Gervassi
  19. Kim M. Murray
  20. Henry Kaplan
  21. John D. Aitchison
  22. James R. Heath
  23. D. Noah Sather
  24. Jason D. Goldman
  25. Lisa Frenkel
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Abstract

BACKGROUND

Coronavirus disease 2019 ( COVID-19 ) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor ( AT1R-Ab ).

METHODS

We compared prevalence and levels of AT1R-Ab in COVID-19 cases with mild or severe disease to age and sex matched negative controls.

RESULTS

There were no significant differences between cases and controls. However, there were trends toward a higher proportion with AT1R-Ab positivity among severe cases versus controls (32% vs. 11%, p=0.1) and higher levels in those with mild COVID-19 compared to controls (median 9.5U/mL vs. 5.9U/mL, p=0.06).

CONCLUSIONS

These findings suggest that AT1R-Ab are not consistently associated with COVID-19 but do not exclude a contribution to endothelial pathology in a subset of people.

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