Preserved C-reactive protein responses to blood stream infections following tocilizumab treatment for COVID-19

  1. Emmanuel Q Wey
  2. Clare Bristow
  3. Aarti Nandani
  4. Bryan O’Farrell
  5. Jay Pang
  6. Marisa Lanzman
  7. Shuang Yang
  8. Soo Ho
  9. Damien Mack
  10. Michael Spiro
  11. Indran Balakrishnan
  12. Sanjay Bhagani
  13. Gabriele Pollara
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Abstract

C-reactive protein (CRP) levels are elevated following bacterial infections but may be attenuated by the IL-6-receptor antagonist tocilizumab. In hospitalised COVID-19 patients, tocilizumab induced a transient (<21 day) fall in CRP but retained CRP responses to nosocomial blood stream infections, and therefore its utility in guiding antibiotic prescribing.

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