Association between reactogenicity and SARS-CoV-2 antibodies after the second dose of the BNT162b2 COVID-19 vaccine

  1. Shohei Yamamoto
  2. Ami Fukunaga
  3. Akihito Tanaka
  4. Junko S. Takeuchi
  5. Yosuke Inoue
  6. Moto Kimura
  7. Kenji Maeda
  8. Gohzoh Ueda
  9. Tetsuya Mizoue
  10. Mugen Ujiie
  11. Wataru Sugiura
  12. Norio Ohmagari
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Abstract

High vaccine reactogenicities may reflect stronger immune responses, but the epidemiological evidence for coronavirus disease 2019 (COVID-19) vaccines is sparse and inconsistent. We observed that a fever of ≥38□ after two doses of the BNT162b2 vaccine was associated with higher severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike IgG titers.

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