Sex–associated differences between body mass index and SARS-CoV-2 antibody titers following the BNT162b2 vaccine among 2,435 healthcare workers in Japan

  1. Shohei Yamamoto
  2. Tetsuya Mizoue
  3. Akihito Tanaka
  4. Yusuke Oshiro
  5. Natsumi Inamura
  6. Maki Konishi
  7. Mitsuru Ozeki
  8. Kengo Miyo
  9. Wataru Sugiura
  10. Haruhito Sugiyama
  11. Norio Ohmagari
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Abstract

Obesity may downregulate vaccine-induced immunogenicity, but the epidemiological evidence for the COVID-19 vaccine is limited, and the sex-associated difference is unknown. It was observed that a higher body mass index was associated with lower titers of spike IgG antibodies against SARS-CoV-2 in men but not in women.

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