De Novo Whole Genome Assembly of the Roborovski Dwarf Hamster (Phodopus roborovskii) Genome, an Animal Model for Severe/Critical COVID-19

  1. Sandro Andreotti
  2. Janine Altmüller
  3. Claudia Quedenau
  4. Tatiana Borodina
  5. Geraldine Nouailles
  6. Luiz Gustavo Teixeira Alves
  7. Markus Landthaler
  8. Maximilian Bieniara
  9. Jakob Trimpert
  10. Emanuel Wyler
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Abstract

The Roborovski dwarf hamster Phodopus roborovskii belongs to the Phodopus genus, one of seven within Cricetinae subfamily. Like other rodents such as mice, rats or ferrets, hamsters can be important animal models for a range of diseases. Whereas the Syrian hamster from the genus Mesocricetus is now widely used as a model for mild to moderate COVID-19, Roborovski dwarf hamster show a severe to lethal course of disease upon infection with the novel human coronavirus SARS-CoV-2.

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