A sensitive and specific genetically encodable biosensor for potassium ions

  1. Sheng-Yi Wu
  2. Yurong Wen
  3. Nelson Bernard Calixte Serre
  4. Cathrine Charlotte Heiede Laursen
  5. Andrea Grostøl Dietz
  6. Brian R. Taylor
  7. Abhi Aggarwal
  8. Vladimir Rancic
  9. Michael Becker
  10. Klaus Ballanyi
  11. Kaspar Podgorski
  12. Hajime Hirase
  13. Maiken Nedergaard
  14. Matyáš Fendrych
  15. M. Joanne Lemieux
  16. Daniel F. Eberl
  17. Alan R. Kay
  18. Robert E. Campbell
  19. Yi Shen
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Abstract

Potassium ions (K + ) play a critical role as an essential electrolyte in all biological systems. Here we report the crystal structure-guided optimization and directed evolution of an improved genetically encoded fluorescent K + biosensor, GINKO2. GINKO2 is highly sensitive and specific for K + and enables in vivo detection of K + dynamics in multiple species.

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