Durability of antibody responses and frequency of clinical and subclinical SARS-CoV-2 infection six months after BNT162b2 COVID-19 vaccination in healthcare workers

  1. Eric D. Laing
  2. Carol D. Weiss
  3. Emily C. Samuels
  4. Si’Ana A. Coggins
  5. Wei Wang
  6. Richard Wang
  7. Russell Vassell
  8. Spencer L. Sterling
  9. Marana A. Tso
  10. Tonia Conner
  11. Emilie Goguet
  12. Matthew Moser
  13. Belinda M. Jackson-Thompson
  14. Luca Illinik
  15. Julian Davies
  16. Orlando Ortega
  17. Edward Parmelee
  18. Monique Hollis-Perry
  19. Santina E. Maiolatesi
  20. Gregory Wang
  21. Kathleen F. Ramsey
  22. Anatalio E. Reyes
  23. Yolanda Alcorta
  24. Mimi A. Wong
  25. Alyssa R. Lindrose
  26. Christopher A. Duplessis
  27. David R. Tribble
  28. Allison M.W. Malloy
  29. Timothy H. Burgess
  30. Simon D. Pollett
  31. Cara H. Olsen
  32. Christopher C. Broder
  33. Edward Mitre
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Abstract

Antibodies against SARS-CoV-2 decay but persist six months post-vaccination, with lower levels of neutralizing titers against Delta than wild-type. Only 2 of 227 vaccinated healthcare workers experienced outpatient symptomatic breakthrough infections despite 59 of 227 exhibiting serological evidence of exposure to SARS-CoV-2 as defined by development of anti-nucleocapsid protein antibodies.

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