Higher mortality associated with the SARS-CoV-2 Delta variant in the Western Cape, South Africa, using RdRp target delay as a proxy

  1. Hannah Hussey
  2. Mary-Ann Davies
  3. Alexa Heekes
  4. Carolyn Williamson
  5. Ziyaad Valley-Omar
  6. Diana Hardie
  7. Stephen Korsman
  8. Deelan Doolabh
  9. Wolfgang Preiser
  10. Tongai Maponga
  11. Arash Iranzadeh
  12. Susan Engelbrecht
  13. Sean Wasserman
  14. Neshaad Schrueder
  15. Linda Boloko
  16. Greg Symons
  17. Peter Raubenheimer
  18. Abraham Viljoen
  19. Arifa Parker
  20. Cheryl Cohen
  21. Waasila Jassat
  22. Richard Lessells
  23. Robert J Wilkinson
  24. Andrew Boulle
  25. Nei-yuan Hsiao
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Abstract

A novel proxy for the Delta variant, RNA-dependent RNA polymerase target delay in the Seegene Allplex™ 2019-nCoV PCR assay, was associated with higher mortality (adjusted Odds Ratio 1.45 [95%CI 1.13-1.86]), compared to presumptive Beta infection, in the Western Cape, South Africa (April-July 2021). Prior diagnosed infection and vaccination were protective.

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