Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

  1. Megumi Kishimoto-Urata
  2. Shinji Urata
  3. Ryoji Kagoya
  4. Fumiaki Imamura
  5. Shin Nagayama
  6. Rachel A. Reyna
  7. Junki Maruyama
  8. Tatsuya Yamasoba
  9. Kenji Kondo
  10. Sanae Hasegawa-Ishii
  11. Slobodan Paessler
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Abstract

The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.

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