Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

  1. Richard FitzGerald
  2. Laura Dickinson
  3. Laura Else
  4. Thomas Fletcher
  5. Colin Hale
  6. Alieu Amara
  7. Lauren Walker
  8. Sujan Dilly Penchala
  9. Rebecca Lyon
  10. Victoria Shaw
  11. William Greenhalf
  12. Katie Bullock
  13. Lara Lavelle-Langham
  14. Helen Reynolds
  15. Wendy Painter
  16. Wayne Holman
  17. Sean Ewings
  18. Gareth Griffiths
  19. Saye Khoo
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Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 ( <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="clintrialgov" xlink:href="NCT04746183">NCT04746183</ext-link> ). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma ( p <0.0001).

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