Comparison of the Immunogenicity of five COVID-19 vaccines in Sri Lanka

  1. Chandima Jeewandara
  2. Inoka Sepali Aberathna
  3. Saubhagya Danasekara
  4. Laksiri Gomes
  5. Suranga Fernando
  6. Dinuka Guruge
  7. Thushali Ranasinghe
  8. Banuri Gunasekera
  9. Achala Kamaladasa
  10. Heshan Kuruppu
  11. Gayasha Somathilake
  12. Jeewantha Jayamali
  13. Deshni Jayathilaka
  14. Helanka Dinesh Kumara Wijayatilake
  15. Pradeep Darshana Pushpakumara
  16. Michael Harvie
  17. Thashmi Nimasha
  18. Shiromi Devika Grace de Silva
  19. Ruwan Wijayamuni
  20. Lisa Schimanski
  21. Pramila Rijal
  22. Jack Tan
  23. Alain Townsend
  24. Graham S. Ogg
  25. Gathsaurie Neelika Malavige
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Abstract

We assessed antibody responses 3 months post-vaccination in those who received mRNA-1273 (n=225), Sputnik V (n=128) or the first dose of Gam-COVID-Vac (n=184) and compared the results with previously reported data of Sinopharm and AZD1222 vaccinees. 99.5% of Moderna >94% of AZD1222 or Sputnik V, 72% to 76% of Gam-COVID-Vac (first dose) and 38.1% to 68.3% of Sinopharm vaccinees had ACE2 blocking antibodies above the positive threshold. The ACE2 blocking antibody levels were highest to lowest was Moderna > Sputnik V/ AZD1222 (had equal levels)> first dose of Gam-COVID-Vac > Sinopharm. All Moderna recipients had antibodies above the positive threshold to the ancestral (WT), B.1.1.7, B.1.351.1 and 80% positivity rate for B.1.617.2. Positivity rates of Sputnik V vaccinees for WT and variants, were higher than AZD1222 vaccinees, while Sinopharm vaccinees had the lowest positivity rates (<16.7%). These findings highlight the need for further studies to understand the effects on clinical outcomes.

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