Increased risk of infection with SARS-CoV-2 Omicron compared to Delta in vaccinated and previously infected individuals, the Netherlands, 22 November to 19 December 2021

  1. Dirk Eggink
  2. Stijn P. Andeweg
  3. Harry Vennema
  4. Noortje van Maarseveen
  5. Klaas Vermaas
  6. Boris Vlaemynck
  7. Raf Schepers
  8. Arianne B. van Gageldonk-Lafeber
  9. Susan van den Hof
  10. Chantal B.E.M. Reusken
  11. Mirjam J. Knol
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Abstract

Infections by the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 70,983 infected individuals (age ≥ 12 years), we observed an increased risk of S-gene target failure, predictive of the Omicron variant, in fully vaccinated (odds ratio: 5.0; 95% confidence interval: 4.0-6.1) and previously infected individuals (OR: 4.9: 95% CI: 3.1-7.7) compared with infected naïve individuals. This suggests a substantial decrease in protection from vaccine- or infection-induced immunity against SARS-CoV-2 infections caused by the Omicron variant compared with the Delta variant.

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