Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for SARS-CoV-2 infection and SARS-CoV-2 Related Hospitalizations: A Statewide Report from the Minnesota Electronic Health Record Consortium

  1. Paul E Drawz
  2. Malini DeSilva
  3. Peter Bodurtha
  4. Gabriela Vazquez Benitez
  5. Anne Murray
  6. Alanna M Chamberlain
  7. R Adams Dudley
  8. Stephen Waring
  9. Anupam B Kharbanda
  10. Daniel Murphy
  11. Miriam Halstead Muscoplat
  12. Victor Melendez
  13. Karen L Margolis
  14. Lynn McFarling
  15. Roxana Lupu
  16. Tyler N.A. Winkelman
  17. Steve Johnson
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Abstract

Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a two-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elderly and those with comorbidities. These results support the case for COVID-19 boosters.

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