Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation

  1. Elizabeth S. Taglauer
  2. Yashoda Dhole
  3. Jeffery Boateng
  4. Jennifer Snyder-Cappione
  5. Samantha E. Parker
  6. Katherine Clarke
  7. Lillian Juttukonda
  8. Jean Devera
  9. Jessica Hunnewell
  10. Elizabeth Barnett
  11. Hongpeng Jia
  12. Christina Yarrington
  13. Vishakha Sabharwal
  14. Elisha M. Wachman
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Abstract

Objective

SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy.

Study Design

Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay.

Results

In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p<0.05) and IL-8 uniquely elevated in COVID infant samples (p<0.05). Significant elevations in IL-6, IP-10 and IL-8 were found among both early (1 st /2 nd Trimester) and late (3 rd Trimester) maternal SARS-CoV-2 infections.

Conclusions

Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.

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