Generation of novel SARS-CoV-2 variants on B.1.1.7 lineage in three patients with advanced HIV disease

  1. Anna C. Riddell
  2. Beatrix Kele
  3. Kathryn Harris
  4. Jon Bible
  5. Maurice Murphy
  6. Subathira Dakshina
  7. Nathaniel Storey
  8. Dola Owoyemi
  9. Corinna Pade
  10. Joseph M. Gibbons
  11. David Harrington
  12. Eliza Alexander
  13. Áine McKnight
  14. Teresa Cutino-Moguel
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Abstract

The emergence of new SARS-COV-2 variants is of public health concern in case of vaccine escape. Described are three patients with advanced HIV-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations which are associated with increased transmissibility and immune escape.

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