Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK)

  1. Giulia Vivaldi
  2. David A Jolliffe
  3. Sian Faustini
  4. Hayley Holt
  5. Natalia Perdek
  6. Mohammad Talaei
  7. Florence Tydeman
  8. Emma S Chambers
  9. Weigang Cai
  10. Wenhao Li
  11. Joseph M Gibbons
  12. Corinna Pade
  13. Áine McKnight
  14. Seif O Shaheen
  15. Alex G Richter
  16. Adrian R Martineau
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Abstract

In this population-based cohort of 7530 adults, combined IgG/A/M anti-Spike titres measured after SARS-CoV-2 vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure including household overcrowding, public transport use, and visits to indoor public places.

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