CoDNaS-Q: a database of conformational diversity of the native state of proteins with quaternary structure

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Abstract

Summary

A collection of conformers that exist in a dynamical equilibrium defines the native state of a protein. The structural differences between them describe their conformational diversity, a defining characteristic of the protein with an essential role in multiple cellular processes. Since most proteins carry out their functions by assembling into complexes, we have developed CoDNaS-Q, the first online resource to explore conformational diversity in homooligomeric proteins. It features a curated collection of redundant protein structures with known quaternary structure. CoDNaS-Q integrates relevant annotations that allow researchers to identify and explore the extent and possible reasons of conformational diversity in homooligomeric protein complexes.

Availability and implementation

CoDNaS-Q is freely accessible at <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://ufq.unq.edu.ar/codnasq/">http://ufq.unq.edu.ar/codnasq/</ext-link>. The data can be retrieved from the website. The source code of the database can be downloaded from <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://github.com/SfrRonaldo/codnas-q">https://github.com/SfrRonaldo/codnas-q</ext-link>.

Contact

<email>npalopoli@unq.edu.ar</email>

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