Cross-neutralizing activity against Omicron could be obtained in SARS-CoV-2 convalescent patients who received two doses of mRNA vaccination

  1. Yukiya Kurahashi
  2. Koichi Furukawa
  3. Silvia Sutandhio
  4. Lidya Handayani Tjan
  5. Sachiyo Iwata
  6. Shigeru Sano
  7. Yoshiki Tohma
  8. Hiroyuki Ohkita
  9. Sachiko Nakamura
  10. Mitsuhiro Nishimura
  11. Jun Arii
  12. Tatsunori Kiriu
  13. Masatsugu Yamamoto
  14. Tatsuya Nagano
  15. Yoshihiro Nishimura
  16. Yasuko Mori
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Abstract

The SARS-CoV-2 variant Omicron is now under investigation. We evaluated cross-neutralizing activity against Omicron in COVID-19 convalescent patients (n=23) who had received two doses of an mRNA vaccination (BNT162b2 or mRNA-1273). Surprisingly and interestingly, after the second vaccination, the subjects’ neutralizing antibody titers including that against Omicron all became seropositive, and significant fold-increases (21.1–52.0) were seen regardless of the subjects’ disease severity. Our findings thus demonstrate that at least two doses of mRNA vaccination to SARS-CoV-2 convalescent patients can induce cross-neutralizing activity against Omicron.

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