Potency and Breadth of Neutralization after 3 doses of mRNA vaccines in COVID-19 Convalescent and Naïve individuals

  1. Joanna Luczkowiak
  2. Gonzalo Rivas
  3. Nuria Labiod
  4. Fátima Lasala
  5. Marta Rolo
  6. Jaime Lora-Tamayo
  7. Mikel Mancheno-Losa
  8. David Rial-Crestelo
  9. Alfredo Pérez-Rivilla
  10. María D. Folgueira
  11. Rafael Delgado
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Abstract

Third doses of mRNA COVID-19 vaccines induced a significant increase in neutralizing potency and breadth in naïve individuals comparable with convalescents who restored levels after the first two doses. These results suggest a limit to elicit neutralization in the number of stimuli by infection or vaccination with ancestral SARS-CoV-2 sequences

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