Identification of a Novel SARS-CoV-2 Delta-Omicron Recombinant Virus in the United States

  1. Kristine A. Lacek
  2. Benjamin L. Rambo-Martin
  3. Dhwani Batra
  4. Xiao-yu Zheng
  5. Hitoshi Sakaguchi
  6. Thomas Peacock
  7. Matthew Keller
  8. Malania M. Wilson
  9. Mili Sheth
  10. Morgan L. Davis
  11. Mark Borroughs
  12. Jonathan Gerhart
  13. Norman Hassell
  14. Samuel S. Shepard
  15. Peter W. Cook
  16. Justin Lee
  17. David E. Wentworth
  18. John R. Barnes
  19. Rebecca Kondor
  20. Clinton R. Paden
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Abstract

Recombination between SARS-CoV-2 virus variants can result in different viral properties (e.g., infectiousness or pathogenicity). In this report, we describe viruses with recombinant genomes containing signature mutations from Delta and Omicron variants. These genomes are the first evidence for a Delta-Omicron hybrid Spike protein in the United States.

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