Androgen receptor polyQ alleles and COVID-19 severity in men: a replication study

  1. Rosario López-Rodríguez
  2. Javier Ruiz-Hornillos
  3. Marta Cortón
  4. Berta Almoguera
  5. Pablo Minguez
  6. María Elena Pérez-Tomás
  7. María Barreda-Sánchez
  8. Esther Mancebo
  9. Lorena Ondo
  10. Andrea Martinez-Ramas
  11. Lidia Fernández-Caballero
  12. the STOP_Coronavirus Study Group
  13. Estela Paz-Artal
  14. Encarna Guillen-Navarro
  15. Carmen Ayuso
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Abstract

Ample evidence indicates a sex-related difference in severity of COVID-19, with less favorable outcomes observed in men. Genetic factors have been proposed as candidates to explain this difference. The polyQ polymorphism in the androgen receptor gene has been recently described as a genetic biomarker of COVID-19 severity. In this study, we analyzed this association in a large cohort of 1136 men classified into three groups according to their degree of COVID-19 severity, finding a similar distribution of polyQ alleles among severity groups. Therefore, our results do not support the role of this polymorphism as a biomarker of COVID-19 severity.

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