Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping

  1. Yang Liu
  2. Marcello DiStasio
  3. Graham Su
  4. Hiromitsu Asashima
  5. Archibald Enninful
  6. Xiaoyu Qin
  7. Yanxiang Deng
  8. Pino Bordignon
  9. Marco Cassano
  10. Mary Tomayko
  11. Mina Xu
  12. Stephanie Halene
  13. Joseph E. Craft
  14. David Hafler
  15. Rong Fan
1 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

We present spatial-CITE-seq for high-plex protein and whole transcriptome co-mapping, which was firstly demonstrated for profiling 189 proteins and transcriptome in multiple mouse tissue types. It was then applied to human tissues to measure 273 proteins and transcriptome that revealed spatially distinct germinal center reaction in tonsil and early immune activation in skin at the COVID-19 mRNA vaccine injection site. Spatial-CITE-seq may find a range of applications in biomedical research.

Related articles

Related articles are currently not available for this article.