Effectiveness of COVID-19 mRNA vaccine booster dose relative to primary series during a period of Omicron circulation

  1. Joshua G. Petrie
  2. Jennifer P. King
  3. David L. McClure
  4. Melissa A. Rolfes
  5. Jennifer K. Meece
  6. Edward A. Belongia
  7. Huong Q. McLean
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Abstract

During a period of Omicron variant circulation, we estimated relative VE of COVID-19 mRNA booster vaccination versus primary two-dose series in an ongoing community cohort. Relative VE was 66% (95% CI: 46%, 79%) favoring the booster dose compared to primary series vaccination. Our results support current booster recommendations.

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