Accident and emergency (AE) attendance in England following infection with SARS-CoV-2 Omicron or Delta

  1. Daniel J. Grint
  2. Kevin Wing
  3. Hamish P. Gibbs
  4. Stephen JW Evans
  5. Elizabeth Williamson
  6. Krishnan Bhaskaran
  7. Helen I McDonald
  8. Alex J. Walker
  9. David Evans
  10. George Hickman
  11. Rohini Mathur
  12. Anna Schultze
  13. Christopher T Rentsch
  14. John Tazare
  15. Ian J Douglas
  16. Helen J. Curtis
  17. Caroline E Morton
  18. Sebastian Bacon
  19. Simon Davy
  20. Brian MacKenna
  21. Peter Inglesby
  22. Richard Croker
  23. John Parry
  24. Frank Hester
  25. Sam Harper
  26. Nicholas J DeVito
  27. Will Hulme
  28. Chris Bates
  29. Jonathon Cockburn
  30. Amir Mehrkar
  31. Ben Goldacre
  32. Rosalind M. Eggo
  33. Laurie Tomlinson
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Abstract

The SARS-CoV-2 Omicron variant is increasing in prevalence around the world. Accurate estimation of disease severity associated with Omicron is critical for pandemic planning. We found lower risk of accident and emergency (AE) attendance following SARS-CoV-2 infection with Omicron compared to Delta (HR: 0.39 (95% CI: 0.30 – 0.51; P<.0001). For AE attendances that lead to hospital admission, Omicron was associated with an 85% lower hazard compared with Delta (HR: 0.14 (95% CI: 0.09 – 0.24; P<.0001)).

Conflicts of Interests

Nothing to declare.

Funding statement

This work was supported by the Medical Research Council MR/V015737/1. TPP provided technical expertise and infrastructure within their data centre pro bono in the context of a national emergency. Rosalind Eggo is funded by HDR UK (grant: MR/S003975/1), MRC (grant: MC_PC 19065), NIHR (grant: NIHR200908).

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