COVID-19 vaccine effectiveness during a prison outbreak when the Omicron was the dominant circulating variant— Zambia, December 2021

  1. John Simwanza
  2. Jonas Z. Hines
  3. Danny Sinyange
  4. Nyambe Sinyange
  5. Chilufya Mulenga
  6. Sarah Hanyinza
  7. Patrick Sakubita
  8. Nelia Langa
  9. Haggai Nowa
  10. Priscilla Gardner
  11. Ngonda Saasa
  12. Gabriel Chipeta
  13. James Simpungwe
  14. Warren Malambo
  15. Busiku Hamainza
  16. Nathan Kapata
  17. Muzala Kapina
  18. Kunda Musonda
  19. Mazyanga Liwewe
  20. Consity Mwale
  21. Sombo Fwoloshi
  22. Lloyd B. Mulenga
  23. Simon Agolory
  24. Victor Mukonka
  25. Roma Chilengi
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Abstract

During a COVID-19 outbreak in a prison in Zambia from 14 th to 19 th December 2021, a case control study was done to measure vaccine effectiveness (VE) against infection and symptomatic infection, when the Omicron variant was the dominant circulating variant. Among 382 participants, 74.1% were fully vaccinated and the median time since full vaccination was 54 days. There were no hospitalizations or deaths. COVID-19 VE against any SARS-CoV-2 infection was 64.8% and VE against symptomatic SARS-CoV-2 infection was 72.9%. COVID-19 vaccination helped protect incarcerated persons against SARS-CoV-2 infection during an outbreak while Omicron was the dominant variant in Zambia.

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