Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico

  1. Hugo G. Castelán-Sánchez
  2. Luis Delaye
  3. Rhys P. D. Inward
  4. Simon Dellicour
  5. Bernardo Gutierrez
  6. Natalia Martinez de la Vina
  7. Celia Boukadida
  8. Oliver G Pybus
  9. Guillermo de Anda Jáuregui
  10. Plinio Guzmán
  11. Marisol Garrido Flores
  12. Óscar Fontanelli
  13. Maribel Hernández Rosales
  14. Amilcar Meneses
  15. Gabriela Olmedo-Alvarez
  16. Alfredo Herrera-Estrella
  17. Alejandro Sanchez-Flores
  18. José Esteban Muñoz-Medina
  19. Andreu Comas-García
  20. Bruno Gómez-Gil
  21. Selene Zárate
  22. Blanca Taboada
  23. Susana López
  24. Carlos F. Arias
  25. Moritz U.G. Kraemer
  26. Antonio Lazcano
  27. Marina Escalera-Zamudio
4 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

Over 200 different SARS-CoV-2 lineages have been observed in Mexico by November 2021. To investigate lineage replacement dynamics, we applied a phylodynamic approach and explored the evolutionary trajectories of five dominant lineages that circulated during the first year of local transmission. For most lineages, peaks in sampling frequencies coincided with different epidemiological waves of infection in Mexico. Lineages B.1.1.222 and B.1.1.519 exhibited similar dynamics, constituting clades that likely originated in Mexico and persisted for >12 months. Lineages B.1.1.7, P.1 and B.1.617.2 also displayed similar dynamics, characterized by multiple introduction events leading to a few successful extended local transmission chains that persisted for several months. For the largest B.1.617.2 clades, we further explored viral lineage movements across Mexico. Many clades were located within the south region of the country, suggesting that this area played a key role in the spread of SARS-CoV-2 in Mexico.

Related articles

Related articles are currently not available for this article.