AlphaPulldown – a Python package for protein-protein interaction screens using AlphaFold-Multimer
Abstract
Summary
The Artificial Intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy. Increasingly, AlphaFold-Multimer is also used to discover new protein-protein interactions. Here, we present AlphaPulldown, a Python package that streamlines protein-protein interaction screens and high-throughput modelling of higher-order oligomers using AlphaFold-Multimer. It provides a convenient command line interface, a variety of confidence scores, and a graphical analysis tool.
Availability and implementation
AlphaPulldown is freely available at <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.embl-hamburg.de/AlphaPulldown">https://www.embl-hamburg.de/AlphaPulldown</ext-link>.
Related articles
Related articles are currently not available for this article.