An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

  1. Lai Wei
  2. Shuiqing Liu
  3. Shanshan Lu
  4. Shengdong Luo
  5. Xiaoping An
  6. Huahao Fan
  7. Weiwei Chen
  8. Erguang Li
  9. Yigang Tong
  10. Lihua Song
2 evaluations Published on
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Abstract

SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it an invaluable surrogate model for evaluating the efficacy of drugs and vaccines against SARS-CoV-2.

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