A wheat tandem kinase sensor activates an NLR helper to trigger immunity

  1. Renjie Chen
  2. Jian Chen
  3. Megan A. Outram
  4. Oliver R. Powell
  5. Taj Arndell
  6. Karthick Gajendiran
  7. Yan L. Wang
  8. Michael A. Ayliffe
  9. Cheryl Blundell
  10. Melania Figueroa
  11. Jana Sperschneider
  12. Thomas Vanhercke
  13. Dingzhong Tang
  14. Yang Xu
  15. Guitao Zhong
  16. Catherine Gardener
  17. Guotai Yu
  18. Spyridon Gourdoupis
  19. Łukasz Jaremko
  20. Oadi Matny
  21. Brian J. Steffenson
  22. Willem H. P. Boshoff
  23. Wilku B. Meyer
  24. Stefan T. Arold
  25. Peter N. Dodds
  26. Brande B. H. Wulff
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Abstract

Most plant resistance genes encode membrane-anchored receptor-like proteins or intracellular nucleotide-binding and leucine-rich repeat (NLR) receptors. In wheat and barley, tandem kinases (TKs) have emerged as a new class of resistance determinants. To understand the modus operandi of the wheat stem rust resistance protein Sr62TK, we identified two genetic interactors— a host gene required for Sr62TKfunction and the corresponding fungal AvrSr62 effector. We discovered that theSR62locus consists of a digenic module encoding Sr62TKand an NLR (Sr62NLR). AvrSr62 binds to the N-terminal kinase of Sr62TK. This triggers displacement of the C-terminal kinase allowing it to recruit Sr62NLRfor activation of immune responses. Understanding the mechanism of this two-component resistance complex will help engineering and breeding for durable resistance.

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