Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture

  1. Viktoria Kohlhas
  2. Hendrik Jestrabek
  3. Rocio Rebollido-Rios
  4. Thanh Tung Truong
  5. Rebekka Zölzer
  6. Luca D. Schreurs
  7. Anton von Lom
  8. Alexander F. vom Stein
  9. Michael Hallek
  10. Phuong-Hien Nguyen
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Abstract

In this brief report, we evaluated various macrophage coculture systems for their CLL-feeding potential, phagocytosis capacity, induction of treatment resistance in CLL cells, and their impact on the transcriptional profiles of CLL cells.

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