SVelfie: A method for discovering cancer drivers based on enrichment of likely functional structural variants

Structural variants (SVs) can drive tumorigenesis, yet discovering SV cancer drivers remains challenging ¹ . Here, we present SVelfie ( <underline>S</underline> tructural <underline>V</underline> ariants <underline>e</underline> nriched with l ikely <underline>f</underline> unctional/ i mpactful <underline>e</underline> vents), a statistical method to infer driver genes from SVs detected across a cohort of cancer genomes, based on enrichment of likely functional events. When testing SVelfie on lymphoma samples from the Pan-Cancer Analysis of Whole Genomes (PCAWG) ² , it corroborates known tumor suppressor genes and also yields novel driver candidates.