AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt

Synchronizing protein structure predictions with sequence databases is crucial for their accuracy. We developed AlphaSync (<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://alphasync.stjude.org">alphasync.stjude.org</ext-link>), a pipeline and database that provides updated AlphaFold structure models for currently 39,961 UniProt proteins, including isoforms. Moreover, AlphaSync enhances 2.6 million structures with residue-level features, including solvent accessibility, dihedral angles, intrinsic disorder predictions, and 4.7 billion atom-level noncovalent contacts. AlphaSync’s user-friendly interface enables structural analyses at scale across up-to-date proteomes for 42 species.