Aging-related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline and age at onset in Alzheimer’s disease
Abstract
INTRODUCTION
Aging is the strongest risk factor for Alzheimer’s disease (AD) characterized by amyloid-β (Aβ) plaques and tau tangles in the brain. We aim to compare biological aging-related biomarkers among AD, non-neurodegenerative control (NDC) and non-AD neurodegenerative disease (Non-AD) individuals to evaluate their clinical utility.
METHODS
We included 137 participants (37 NDC, 67 AD, 33 Non-AD) from the UCL Dementia Research Centre and measured matrix metallopeptidase 10 (MMP-10), osteopontin (OPN), neurofilament-light, and glial fibrillary acidic protein in cerebrospinal fluid (CSF) samples in addition to Aβ/pTau and clinical parameters.
RESULTS
Elevated MMP-10 associated with poorer cognition and later onset specifically in AD, whereas elevated OPN associated with CSF Aβ and tau pathology. MMP-10 and OPN levels improved the differentiation of AD from NDC, and AD from Non-AD, respectively.
DISCUSSION
Our study provides evidence on potential clinical utility of CSF MMP-10 and OPN in AD diagnosis and supports taking biological aging into consideration in AD research.
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